MEDLINE/PubMed Journal Browser Search

Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

Title: [Dysfunctional resting-state connectivity of default mode network in adolescent patients with first-episode drug-naive major depressive disorder].
Author: Li SY, Zhu Y, Wang YL, Lü PP, Zuo WB, Li FY.
Journal: Zhonghua Yi Xue Za Zhi; 2017 Dec 05; 97(45):3538-3542. PubMed ID: 29275591.
Abstract:
Objective: To study resting-state functional connectivity (FC) of default mode network (DMN) in adolescent patients with first-episode drug-naive major depressive disorder (MDD). Methods: We enrolled thirty first-episode and drug-naive adolescent MDD patients and twenty-nine adolescent healthy control (HC) participants in the First Affiliated Hospital of Zhengzhou University. There were no differences in age, sex, and education between the MDD and HC group. Resting-state functional magnetic resonance images (fMRI) was performed. We selected posterior cingulate cortex (PCC) and medial prefrontal cortex (MPFC) of DMN as regions of interests (ROI). The differences of these regions from the whole brain functional connectivity were analyzed. The relations between abnormalities in FCs of DMN and clinical variables were further investigated. Results: Compared to the HCs, the MDD patients had congruently reduced FCs between the PCC and cerebellum, temporal cortices, occipital cortices, fusiform, dorsolateral prefrontal cortex. MPFC not only had reduced FCs with fusiform, temporal cortices, anterior cingulate cortex, but also had enhanced FCs with occipital cortices, parietal cortices, and precentral gyrus. In addition, the increased FC between the right MPFC and right precentral gyrus was positive correlated with Hamilton Rating Scale for Depression (HAMD) scores (r=0.38, P=0.04). The reduced FC between the left middle temporal gyrus and left PCC as well as the enhanced FC between the right middle cingulum and right MPFC were positive correlated with the duration of depression since onset (r=0.39, P=0.03; r=0.38, P=0.04). Conclusions: These findings show dysfunctional DMN connectivity of adolescent MDD patients. Neurodevelopmental abnormalities in DMN may present in adolescent MDD. 目的： 研究青少年首发抑郁症(MDD)患者默认网络(DMN)功能连接(FC)改变及其意义。 方法： 选择自2015年1月至2017年1月在郑州大学第一附属医院精神科门诊及病房30例青少年首发MDD患者(患者组)和同期招募29名性别、年龄、受教育程度相匹配健康对照(健康对照组)。采用静息态功能磁共振技术扫描，选取DMN中内侧前额叶皮质(MPFC)和后扣带回(PCC)为感兴趣区，比较患者组与健康对照组MPFC和PCC与全脑脑区FC差异。进一步探讨患者组DMN异常FC与抑郁症状及病程之间关系。 结果： 和健康对照组相比，患者组PCC与小脑、额叶、颞叶、枕叶、梭状回、背外侧前额叶皮质等存在广泛FC降低，而MPFC与梭状回、颞叶、前扣带回等存在FC降低，而与枕叶、顶叶、旁扣带回等存在FC增强。患者组右侧MPFC与中央前回FC增强与汉密尔顿抑郁分数呈正相关(r＝0.38，P＝0.04)。右侧MPFC与右侧旁扣带回FC增强、左侧PCC与左侧颞中回FC下降与病程呈正相关(r＝0.39，P＝0.03；r＝0.38，P＝0.04)。 结论： 青少年抑郁症DMN存在广泛FC异常，可能是其存在情感调节障碍神经学基础。.

[Abstract] [Full Text] [Related] [New Search]