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  • Title: Sertraline-induced Hemichorea.
    Author: Gatto EM, Aldinio V, Parisi V, Persi G, Da Prat G, Bullrich MB, Sanchez P, Rojas G.
    Journal: Tremor Other Hyperkinet Mov (N Y); 2017; 7():518. PubMed ID: 29276648.
    Abstract:
    BACKGROUND: Hemichorea-hemiballism is a syndrome secondary to different etiologies. Drug-induced hemichorea is a rare syndrome related to selective serotonin reuptake inhibitors. To the best of our knowledge, no previous cases of hemichorea associated with sertraline have been reported. CASE REPORT: A 65-year-old female noticed hemichorea 1 week after initiation of sertraline. After extensive investigations, other causes of hemichorea were excluded. Hemichorea remitted after sertraline withdrawal. DISCUSSION: In our patient, temporal association and the negative clinical assessment supported a diagnosis of likely drug-induced involuntary movement. We hypothesized that enhanced serotonergic transmission in the ventral tegmental area or nigrostriatum may be involved in sertraline-induced hemichorea.
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