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  • Title: Retinal astrocytoma regression in tuberous sclerosis patients treated with everolimus.
    Author: Zipori AB, Tehrani NN, Ali A.
    Journal: J AAPOS; 2018 Feb; 22(1):76-79. PubMed ID: 29277498.
    Abstract:
    Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) that has been approved by the US Food and Drug Administration for the treatment of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis complex (TSC). Retinal hamartomas, which are one of the major diagnostic features of TSC, tend to remain stable or gradually progress in the natural history of the disease. We report 2 patients with TSC treated with everolimus for SEGA in whom fundus photographs and spectral domain optical coherence tomography demonstrated regression of previously documented multiple retinal hamartomas in all 4 eyes.
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