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Title: Radiation induced violations of blood circulation in the ciliary body and changes of the anterior chamber angle in the pathogenesis of glaucoma in clean up workers of the Chornobyl NPP accident and residents of contaminated areas.
Author: Garkava NA, Fedirko PA, Babenko TF, Dorichevska RE.
Journal: Probl Radiac Med Radiobiol; 2017 Dec; 22():332-338. PubMed ID: 29286518.
Abstract:
OBJECTIVE: Estimate changes blood filling of the ciliary body and changes of the anterior chamber angle; study their influence to glaucoma pathogenesis in irradiated persons. MATERIALS AND METHODS: Used the results of a randomly selected group survey of 41 clean up workers of the Chornobyl NPP accident (clean up workers), and 18 inhabitants of the zone of guaranteed voluntary resettlement; age at the time of the survey was 45-50 years. The control group consisted of 41 persons of the same age had not radiation exposure. State of the anterior chamber angle studied by gonioscopy, which was conducted 35 clean up workers and 35 persons of the control group. Changes of the blood circulation in the ciliary body examine by the ophtalmoreog raphy, what was done on 12 eyes of 6 clean up workers, control was 12 eyes of 6 persons had not radiation exposure. RESULTS: Detection revealed of the blood circulation in the ciliary body in all clean up workers, reography coefficient was probably lower (p < 0.05), than in the control group. The research of the state of the anterior chamber angle revealed a higher relative risk of appearance of involution changes of the anterior chamber angle in clean up work ers of ChNPP accident, in comparison with the control group was 3.5 (1.27; 9.5) χ2 = 7.48, p = 0.031. The same changes are characteristic for inhabitants of radiation polluted territories. CONCLUSIONS: Influence ionizing radiation causes a blood circulation decrease in the ciliary body and development changes of the angle of the anterior chamber. Presence of these changes can explain the features of the pathogene sis of glaucoma in irradiated late manifestation and, at the same time, severe course. Meta. Otsinyty zminy krovonapovnennia tsiliarnogo tila i stanu kuta peredn'oï kamery oka (KPK) ta vyvchyty ïkh vplyv na patogenez glaukomy u radiatsiy̆no oprominenykh osib.Materialy i metody. Vykorystani rezul'taty obstezhennia vypadkovo vidibranoï grupy z 41 uchasnyka likvidatsiï naslidkiv avariï na Chornobyl's'kiy̆ AES (ULNA na ChAES) i 18 meshkantsiv zony garantovanogo dobrovil'nogo vidselennia; vik na moment obstezhennia 45–50 rokiv. Kontrol'nu grupu stanovyla 41 osoba togo zh viku. Stan ku ta peredn'oï kamery vyvchavsia za dopomogoiu gonioskopiï, zminy krovoobigu v tsiliarnomu tili otsiniuvaly za dopo mogoiu oftal'moreografiï.Rezul'taty. Vyiavleno zmenshennia krovotoku v tsiliarnomu tili u vsikh ULNA. Tak, reografichnyy̆ koefitsiient (RK) v uchasnykiv likvidatsiï naslidkiv avariï na Chornobyl's'kiy̆ AES buv virogidno nyzhchym (p < 0,05) nizh u kontrol'niy̆ grupi. Doslidzhennia stanu KPK vyiavylo vyshchyy̆ ryzyk poiavy involiutsiy̆nykh zmin KPK u ULNA, ranni involiutsiy̆ni zminy KPK vyiavleno u 14 z 35 osib, vidnosnyy̆ ryzyk u porivnianni z kontrol'noiu grupoiu stanovyv 3,5 (1,27; 9,5) χ2= 7,48, p = 0,031. Dlia meshkantsiv radiatsiy̆no zabrudnenykh terytoriy̆ kharakterni taki zh zminy.Vysnovky. Vplyv ionizuiuchoï radiatsiï sprychyniaie znyzhennia krovotoku v sudynnomu trakti ta rozvytok zmin kuta peredn'oï kamery. Naiavnistiu tsykh zmin mozhna poiasnyty osoblyvosti patogenezu glaukomy u radiatsiy̆no op rominenykh pizniy̆ vyiav i tiazhkyy̆ perebig.

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