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  • Title: Alterations in oxygenation of cochlear endolymph during loud sound exposure.
    Author: Thorne PR, Nuttall AL.
    Journal: Acta Otolaryngol; 1989; 107(1-2):71-9. PubMed ID: 2929318.
    Abstract:
    The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1 h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals, compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.
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