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  • Title: Retinal cotton-wool-like spots: a marker for AIDS?
    Author: Pezzi PP, Tamburi S, D'offizi GP, Mezzaroma I, Aiuti F.
    Journal: Ann Ophthalmol; 1989 Jan; 21(1):31-3. PubMed ID: 2930117.
    Abstract:
    The prognostic value of ocular manifestations and its correlation with immune changes in HIV-infected subjects was studied longitudinally with an average follow-up of one year (3-22 months). The most common ocular manifestations were retinal cotton-wool-like spots, observed in 58.8% of AIDS patients and in 76.9% of those with ocular involvement. Two of three ARC cases with cotton-wool-like spots developed Pneumocystis carinii pneumonia a few weeks after ophthalmoscopic examination. A close correlation between ocular changes and decrease of CD4+ lymphocytes was observed. In our opinion, these ocular manifestations are as useful as opportunistic infections or AIDS-related neoplasias in the natural history of HIV infection.
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