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  • Title: Two-dimensional closed-form model for temperature in living tissues for hyperthermia treatments.
    Author: Dutta J, Kundu B.
    Journal: J Therm Biol; 2018 Jan; 71():41-51. PubMed ID: 29301699.
    Abstract:
    This research article determines an exact analytical expression for 2-D thermal field in single layer living tissues under a therapeutic condition by means of Fourier and non-Fourier heat transfer approaches. An actual spatially dependent initial condition has been adopted to analyze the heat propagation in tissues. The exact analytical determination for this actual initial condition for temperature may be difficult. However, in this study, an approximate analytical method has newly been established for an appropriate initial condition. With this initial expression, an exact temperature distribution for 2-D heat conduction in plane co-ordinates has been investigated for the predefined therapeutic boundary condition to have knowledge for practical aspects of the thermal therapy. Laplace Transform Method (LTM) in conjunction with the Inversion Theorem is used for the analytical solution treatment. We have utilized both Pennes' bioheat equation (PBHE) and thermal wave model of bioheat equation (TWMBHE) for the analysis. The influence of thermo-biological behavior on 2-D heat conduction in tissues has been studied with the variation of several dependable parameters in relation to the Hyperthermia treatment protocol in a moderate temperature range (42-45°C). The result in the present study has been evidenced for the biological heat transfer for the enforcement of different circumstances and also has been validated with the published value where the maximum temperature deviation of 2.6% has been recorded. We conclude that the temperature curve for TWMBHE model shows a higher waveform nature for low thermal relaxation time and this wavy nature gradually diminishes with an increase in relaxation time. The maximum peak temperature attains 46.3°C for the relaxation time = 2s and with the increase in the relaxation time the peak temperature gradually falls. The impact of blood perfusion rate on the relaxation time has also been established in this paper.
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