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  • Title: Prefrontal cortex lesions attenuate substantia nigra self-stimulation: a reward summation analysis.
    Author: Silverman JA, Corbett D.
    Journal: Behav Brain Res; 1989 Feb 01; 32(1):43-50. PubMed ID: 2930633.
    Abstract:
    A curve-shift paradigm was used to assess the effects of lesions of the prefrontal cortex on self-stimulation from electrode sites in the substantia nigra. Combined lesions of the medial and sulcal cortical regions severely attenuated substantia nigra self-stimulation. These results are discussed in the context of the frontal cortex and the substantia nigra as belonging to a reinforcement system that is largely independent of the medial forebrain bundle system.
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