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  • Title: Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana.
    Author: Ibrahim SRM, Mohamed GA, Elfaky MA, Al Haidari RA, Zayed MF, El-Kholy AA, Khedr AIM.
    Journal: J Asian Nat Prod Res; 2019 Mar; 21(3):291-297. PubMed ID: 29307236.
    Abstract:
    A new prenylated xanthone, garcixanthone A (5), together with eight known compounds, mangostanaxanthones I (1) and II (2), garcinone E (3), β-mangostin (4), 8-hydroxycudraxanthone G (6), garcinone C (7), cudraxanthone G (8), and (-)-epicatechin (9) were isolated from the EtOAc-soluble fraction of the air-dried pericarps of Garcinia mangostana (family Clusiaceae). Their structures were verified on the basis of spectroscopic data interpretation as well as comparison with the literature. The cytotoxic and antimicrobial activities of the new compound were assessed using sulforhodamine B (SRB) and agar disk diffusion assays, respectively. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma (A549) and breast carcinoma (MCF7) cell lines with IC50s 3.0 and 4.2 μM, respectively, compared to doxorubicin (0.74 and 0.41 μM, respectively).
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