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  • Title: Does platelet serotonin receptor supersensitivity accompany endogenous depression?
    Author: Brusov OS, Beliaev BS, Katasonov AB, Zlobina GP, Factor MI, Lideman RR.
    Journal: Biol Psychiatry; 1989 Feb 15; 25(4):375-81. PubMed ID: 2930807.
    Abstract:
    In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly (p less than 0.001) lower (0.13 +/- 0.0.04 microM) than that of closely matched controls (0.532 +/- 0.1 microM). This platelet concentration becomes higher after 1-3 months of antidepressant treatment (0.47 +/- 0.16 microM). Possible mechanisms for this up- or down-regulation of platelet serotonin receptor responsiveness are discussed.
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