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  • Title: A new putative neuroregulator of the extrapyramidal system.
    Author: Diamond BI, Borison RL.
    Journal: Pharmacology; 1978; 17(4):210-4. PubMed ID: 29315.
    Abstract:
    A putative neurotransmitter, 2-phenylethylamine, which is most highly concentrated in the extrapyramidal system of human brain, is able to reverse reserpine-induced parkinsonism in animals and elicit stereotypy. This action is only partially antagonized after catecholamine depletion by pretreatment with a-methyl-para-tyrosine, and fully blocked by pretreatment with haloperidol, a dopamine receptor blocker. Therefore, via direct and/or indirect actions, 2-phenylethylamine may serve a neuroregulatory role in the extrapyramidal system.
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