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  • Title: Dopaminergic agents differentially alter beta-endorphin processing patterns in the rat pituitary neurointermediate lobe.
    Author: Autelitano DJ, Smith AI, Lolait SJ, Funder JW.
    Journal: Neurosci Lett; 1985 Aug 16; 59(1):141-6. PubMed ID: 2931629.
    Abstract:
    We have established the content and molecular species of immunoreactive beta-endorphin (ir-beta-END) and immunoreactive N-acetyl-endorphin (ir-Nac-END) in rat neurointermediate lobe by specific radioimmunoassay (RIA) and high-performance liquid chromatography after chronic administration of dopamine (DA) agonists and antagonists. The DA agonist, bromocriptine, reduces tissue levels of all major immunoreactive species, in particular the C-terminally shortened N-acetylated forms. The DA antagonist, haloperidol, proportionally increases all immunoreactive forms, except Nac-beta-END, thus altering the relative abundance of this species. These data indicate that DA is involved in the control of both tissue levels and processing of beta-END-like peptides in the rat neurointermediate lobe.
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