These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Discovery of novel 2-substituted-4-phenoxypyridine derivatives as potential antitumor agents.
    Author: Duan Y, Xu S, Xiong H, Wang L, Zhao B, Wang P, Wang C, Peng Y, Cai S, Luo R, Zheng P, Tang Q.
    Journal: Bioorg Med Chem Lett; 2018 Feb 01; 28(3):254-259. PubMed ID: 29317165.
    Abstract:
    A series of 2-substituted-4-phenoxypyridine derivatives were designed, synthesized, and evaluated for their antiproliferative activity against 4 cancer cell lines (A549, HT-29, H460, and U87MG) in vitro. Most compounds showed moderate to excellent potency. Nine tyrosine kinases (c-Met, Flt-3, ALK, VEGFR-2, VEGFR-3, PDGFR-α, PDGFR-β, c-Kit, and EGFR) were used to evaluate the inhibitory activities with the most promising analogue 39, which showed the Flt-3/c-Met IC50 values of 2.18/2.61 nM. Structure-activity relationship studies indicated that n-Pr served as R1 group showed a higher preference, and stronger mono-EWGs on the phenyl ring (such as R2 = 4-F) was benefited to the potency.
    [Abstract] [Full Text] [Related] [New Search]