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  • Title: [Physiological trials with MIF-I in Parkinson's disease (author's transl)].
    Author: Gonce M, Barbeau A.
    Journal: Rev Neurol (Paris); 1978 Feb; 134(2):141-9. PubMed ID: 29330.
    Abstract:
    The writers present some physiological (and not therapeutic) acute and sub-acute trials with tripeptide: L-propyl-L-leucyl-glycine amide (M.I.F.-I) in Parkinson's Disease. This work confirms the earlier observation that M.I.F.-I employed alone or in combination with Levodopa is active against Parkinson's disease. The writers evoke the hypothesis that this action takes place at the postsynaptic receptors, whose configuration may be modified in the sense of a hypersensitivity. These studies justify undertaking a series of controlled therapeutic trials when the cost of the product permits and as well instituting development work on analogues active orally.
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