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  • Title: Rat atrial natriuretic polypeptide stimulation of adrenal zona glomerulosa cell growth.
    Author: Horiba N, Nomura K, Saito Y, Demura H, Shizume K.
    Journal: Biochem Biophys Res Commun; 1985 Oct 15; 132(1):261-3. PubMed ID: 2933032.
    Abstract:
    Rat atrial natriuretic polypeptide (rANP) was found to stimulate [3H] thymidine incorporation into the DNA of bovine adrenal glomerulosa cells in a primary culture in a dose-dependent manner. The minimum effective dose was a very low concentration (10(-12) M of ANP), suggesting that ANP had a physiological effect. These findings are the first indication that ANP possesses growth-stimulating activity with regard to adrenal zona glomerulosa cells.
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