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  • Title: Ectopic Cushing's syndrome secondary to olfactory neuroblastoma.
    Author: Yu K, Roncaroli F, Kearney T, Ewins D, Beeharry D, Naylor T, Ray D, Bhalla R, Gnanalingham K.
    Journal: Acta Neurochir (Wien); 2018 May; 160(5):1023-1026. PubMed ID: 29340776.
    Abstract:
    We present the case of a patient with Cushing's syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient's cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.
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