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  • Title: Inactivation of phi X174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213.
    Author: van Maanen JM, de Ruiter C, Kootstra PR, Lafleur MV, de Vries J, Retèl J, Pinedo HM.
    Journal: Eur J Cancer Clin Oncol; 1985 Oct; 21(10):1215-8. PubMed ID: 2934259.
    Abstract:
    Biologically active phi X174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-phi X174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.
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