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  • Title: Null cell immunoregulation in SLE.
    Author: Stephens HA, Fitzharris P, Knight RA, Snaith ML.
    Journal: J Clin Lab Immunol; 1985 Oct; 18(2):55-61. PubMed ID: 2934551.
    Abstract:
    Fresh normal T cells do not lyse MDA-157 target cells. Normal null cells, cultured for 4 days with MDA-157 stimulators, and then mixed overnight with fresh normal T cells, induce cytotoxicity on MDA-157 targets and suppressor activity in the T-cell acceptor population. With the same normal acceptor T cells, MDA-157 activated null cells from 13/18 patients with Systemic Lupus Erythematosus (SLE), unlike activated cells from a disease control population, induce little or no T-cell cytotoxicity or suppression. These results provide further evidence for abnormal null cell function in SLE.
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