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  • Title: Damages induced in lambda phage DNA by enzyme-generated triplet acetone.
    Author: Menck CF, Cabral-Neto JB, Faljoni-Alário A, Alcantara-Gomes R.
    Journal: Mutat Res; 1986 Jan; 165(1):9-14. PubMed ID: 2934629.
    Abstract:
    Exposure of lambda phage to triplet acetone, generated via the oxidation of isobutanal by peroxidase, leads to genome lesions. The majority of these lesions are detected as DNA single-strand breaks only under alkaline conditions, and so true breaks do not occur. Also, no sites sensitive to UV-endonuclease from Micrococcus luteus were found in DNA from treated phage. The participation of triplet acetone in the generation of such DNA damage is discussed.
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