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  • Title: Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats.
    Author: Sumi R, Miyake A, Endo T, Ohsato Y, Ngo MH, Nishigaki K.
    Journal: Arch Virol; 2018 Apr; 163(4):1073-1077. PubMed ID: 29353423.
    Abstract:
    Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-myc, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of myc transduction usable in clinical diagnosis. The assay targets c-myc exons 2 and 3, which together result in a FeLV-specific fusion gene following c-myc transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors, myc transduction was detected in 14% of T-cell lymphoma/leukemias. This newly established system could become a useful diagnostic tool in veterinary medicine.
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