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  • Title: [A case of duodenal neuroendocrine carcinoma composed of small- and large-cell types].
    Author: Muto M, Ichiki K, Muto M, Ishikawa C, Inoue M, Goto J, Inaba S, Aoki T, Sato K.
    Journal: Nihon Shokakibyo Gakkai Zasshi; 2018; 115(1):79-86. PubMed ID: 29353854.
    Abstract:
    A 78-year-old man underwent a detailed examination by upper gastrointestinal endoscopy for the complaint of epigastric pain. The examination revealed a hemicircumferential type 2 tumor in the descending duodenum. A subsequent biopsy led to a diagnosis of neuroendocrine carcinoma. Subtotal stomach-preserving pancreaticoduodenectomy was performed. The lesion was composed of small- and large-cell neuroendocrine carcinomas. The large-cell type component was positive for both caudal homeobox protein 2 and the cluster of differentiation 138, whereas the small-cell type component was negative for both. Our report may provide valuable information regarding the pathogenesis of neuroendocrine carcinoma.
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