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  • Title: Luteolytic hormones are calcium-mediated, guanine nucleotide antagonists of gonadotropin-sensitive adenylate cyclase.
    Author: Behrman HR, Luborsky JL, Aten RF, Polan ML, Tarlatzis BC, Haseltine FP, Preston SL, Soodak LK, Mattson GF, Chi AS.
    Journal: Adv Prostaglandin Thromboxane Leukot Res; 1985; 15():601-4. PubMed ID: 2936178.
    Abstract:
    We suggest that regression of the corpus luteum is an active process induced by PGF2 alpha, GnRH, and a peptide of ovarian origin whose action GnRH mimics (20). The initial events involved in luteolysis occur within minutes, and they are intimately linked to inhibition of LH action. Membrane receptor binding of luteolytic hormones activates production of a second messenger (such as a product of PI turnover) that stimulates release of sequestered, intracellular Ca2+ by a mechanism linked to inhibition of microsomal Ca2+-ATPase activity. The increase in cytosolic Ca2+ inhibits adenylate cyclase activity by blocking GTP-dependent activation of adenylate cyclase. As a result, the cell response to LH is abolished and function is lost.
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