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  • Title: The effect of locally applied ipratropium aerosol on the nasal methacholine challenge in patients with allergic and non-allergic rhinitis.
    Author: Sanwikarja S, Schmitz PI, Dieges PH.
    Journal: Ann Allergy; 1986 Feb; 56(2):162-6. PubMed ID: 2936282.
    Abstract:
    The effect of local pretreatment with ipratropium versus placebo aerosol on nasal methacholine challenge was studied in a double-blind, crossover trial. Fourteen allergic and ten non-allergic patients suffering from rhinitis participated in this study. It can be concluded that intranasal administration of ipratropium has a suppressive effect on hypersecretion and sneezing, but has no influence on nasal airway resistance.
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