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  • Title: Purification and partial characterization of human lymphoblast interferon.
    Author: Zoon KC, Smith ME, Bridgen PJ, zur Nedden D, Anfinsen CB.
    Journal: Proc Natl Acad Sci U S A; 1979 Nov; 76(11):5601-5. PubMed ID: 293665.
    Abstract:
    One component of human lymphoblastoid interferon obtained from Namalwa cultures induced by Newcastle disease virus has been purified to a specific activity of 2.5 x 10(8) interferon units per mg of protein (protein content based on amino acid analysis). A single polypeptide species with an apparent molecular weight of 18,500 comigrating with the antiviral activity was observed by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Preliminary amino-terminal sequencing results support the conclusion that the interferon species is essentially homogeneous.
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