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  • Title: Oncogenic transformation of mammalian cells in vitro with split doses of x-rays.
    Author: Miller RC, Hall EJ, Rossi HH.
    Journal: Proc Natl Acad Sci U S A; 1979 Nov; 76(11):5755-8. PubMed ID: 293680.
    Abstract:
    An established line of mouse fibroblasts, C3H/10T1/2 cells, was used for the assessment in vitro of oncogenic transformations caused by single and split doses of x-rays. The shape of the dose-response relationship was determined over the range from 0.1 to 10 Gy. It was found that splitting the x-ray dose into two equal fractions, separated by 5 hr, led to a reduction in transformation frequency at doses above 1.5-2 Gy but to an enhancement of transformation at lower doses. The observations reported cast doubt on the assessment of human cancer risk at lo dose levels by a linear extrapolation from available high-dose data from the Japanese atomic bomb survivors or from persons exposed for medical purposes.
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