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  • Title: Cell-cycle-associated rearrangement of inverted repeat DNA sequences.
    Author: Nisen P, Medford R, Mansour J, Purucker M, Skalka A, Shapiro L.
    Journal: Proc Natl Acad Sci U S A; 1979 Dec; 76(12):6240-4. PubMed ID: 293718.
    Abstract:
    Inverted repeat DNA sequences of Caulobacter crescentus have been isolated, characterized, and cloned in a bacteriophage lambda vector. Both whole populations and individual clones of these sequences were hybridized to restriction endonuclease-generated fragments of chromosomal DNA isolated from cells that were in different stages of the cell cycle. Some inverted repeat DNA sequences were observed to hybridize to different regions of the chromosomal DNA isolated from the morphologically and biochemically distinct swarmer cell and stalked cell populations. These results suggest that the inverted repeat sequences have the capacity to rearrange and thus be located at different sites on the genomes of the different cell types.
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