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  • Title: Stimulation of Ca2+-pump in rat heart sarcolemma by phosphatidylethanolamine N-methylation.
    Author: Panagia V, Okumura K, Makino N, Dhalla NS.
    Journal: Biochim Biophys Acta; 1986 Apr 14; 856(2):383-7. PubMed ID: 2937455.
    Abstract:
    Incubation of purified cardiac sarcolemmal vesicles (SL) in the presence of S-adenosyl-L-methionine, a methyl donor for the enzymatic N-methylation of phosphatidylethanolamine (PE), increased the Ca2+-stimulated ATPase and ATP-dependent Ca2+ accumulation activities. Quantitative analysis of the methylated phospholipids revealed that maximal increase of Ca2+-pump activities was associated with predominant synthesis and intramembranal accumulation of phosphatidyl-N,N-dimethylethanolamine. The stimulation of SL Ca2+-pump activities was prevented by inhibitors of PE N-methylation such as S-adenosyl-L-homocysteine and methyl acetimidate hydrochloride. The results suggest a possible role of PE N-methylation in the regulation of Ca2+-transport across the heart SL membrane.
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