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Title: Binding sites for calcium, lipid and p11 on p36, the substrate of retroviral tyrosine-specific protein kinases. Author: Johnsson N, Vandekerckhove J, Van Damme J, Weber K. Journal: FEBS Lett; 1986 Mar 31; 198(2):361-4. PubMed ID: 2937654. Abstract: Biochemical and partial sequence data reveal the two-domain structure of p36. A loose structure of some 30 residues at the amino-terminus contains the phosphorylatable tyrosine and the binding site for the p11 regulatory chain. The following p33 domain retains the lipid-binding site as well as the Ca2+ site which influences the spectral properties of the single tryptophan and one tyrosine. The combined sequence data covering about 25% of the molecule identify p36 as a unique polypeptide.[Abstract] [Full Text] [Related] [New Search]