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  • Title: Anticancer Activity Study of Chromone and Coumarin Hybrids using Electrical Impedance Spectroscopy.
    Author: Bouhenna MM, Mameri N, Pérez MV, Talhi O, Bachari K, Silva AMS, Luyten W.
    Journal: Anticancer Agents Med Chem; 2018; 18(6):854-864. PubMed ID: 29380706.
    Abstract:
    AIMS: Oncology treatments aim at selective toxicity for tumor (compared to normal) cells, and chromone- coumarin hybrids have shown such activity. METHODS: In this study, we test a novel series of synthetic chromone and coumarin derivatives (1-9) for cytotoxic activity against a panel of tumor cell lines (MCF-7, A549, HepG2, HTC-116, B16 and Caco-2) opposed to non-tumor cells (HEK-293t). Electrical impedance spectroscopy was used to monitor cell viability in real time. RESULTS: Compound 8 showed the most potent activity, and it significantly diminished cancer cell proliferation and viability in different cell lines. It induced apoptosis in a dose-dependent manner, as shown by Western blot and flow cytometry. CONCLUSION: Electrical impedance spectroscopy appears to be a convenient tool for in vitro cytotoxicity analysis, which could be useful for identifying drug effects and side effects during early phases of drug discovery and development.
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