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  • Title: [Does weak local gamma irradiation modify the effect of CDDP on mouse mastocytoma?].
    Author: Komatsu K, Nakamura W, Kageyama K.
    Journal: C R Seances Soc Biol Fil; 1985; 179(4):554-7. PubMed ID: 2938682.
    Abstract:
    The possibility that an irradiation with small doses of gamma rays given shortly before might enhance the cure effect of cis-diammine-dichloroplatinum (II) (CDDP) was tested in tumor bearing mice. Tumor cells of FMA3, a cloned cell line of murine mastocytoma, were transplanted in the muscle of a hind leg in one experiment and in the abdominal cavity in another experiment. In both cases, a single injection of CDDP at 4 mg/kg was effective to lengthen the mean survival time of mice. gamma rays at the dose of 1, 2 and 4 Gy given 3 hours before did not modify the effect of CDDP.
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