These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Structural modifications of pro-opiomelanocortin-derived peptides alter their behavioral effects markedly.
    Author: Hirsch MD, O'Donohue TL.
    Journal: J Pharmacol Exp Ther; 1986 May; 237(2):378-85. PubMed ID: 2939234.
    Abstract:
    Previous findings showed that pro-opiomelanocortin-containing neurons and endocrine cells synthesize multiple forms of beta-endorphin (beta E) and alpha-melanocyte-stimulating hormone (alpha-MSH), and that tissue specific post-translational processing of pro-opiomelanocortin can change ratios of the forms of secreted peptides. We therefore investigated the structure-activity requirements for behavioral interactions between beta E1-31 and alpha-MSH. Adult, male Sprague-Dawley rats received i.c.v. administrations of various dose combinations of alpha-MSH and beta E peptides, and behavioral activities were quantitated over a 55-min period. The results showed that both alpha-MSH and beta E1-31 produced dose-related increases in grooming behaviors. alpha-MSH also induced a stretching and yawning syndrome (SYS). beta E1-31 had no effect on SYS but did produce catatonia. BE1-31 inhibited both the grooming and SYS produced by alpha-MSH in a dose-related manner, and alpha-MSH potentiated beta E1-31-induced catatonia. Both N-terminal acetylation and C-terminal modification reduced the effects of beta E1-31 and reduced the inhibition by beta E1-31 of alpha-MSH-induced effects. Although the C-terminal fragments beta E28-31, beta E30-31 and beta E6-31 were devoid of behavioral effects when administered alone, all three peptides inhibited the effects of alpha-MSH on grooming and SYS markedly. Both beta E28-31 and beta E30-31 also inhibited the effects of beta E1-31 and beta E1-27. These results indicate that many of the behavioral actions of beta E1-31 reside in the N-terminus, and modulatory effects on alpha-MSH actions reside in the C-terminus.(ABSTRACT TRUNCATED AT 250 WORDS)
    [Abstract] [Full Text] [Related] [New Search]