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  • Title: A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells.
    Author: Lou LL, Zhao P, Cheng ZY, Guo R, Yao GD, Wang XB, Huang XX, Song SJ.
    Journal: Nat Prod Res; 2019 Jun; 33(12):1791-1793. PubMed ID: 29397774.
    Abstract:
    In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC50 value of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.
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