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  • Title: [Effect of forskolin, isoprenaline and propranolol on spontaneous contractions of the isolated atrium of guinea pigs].
    Author: Varagic VM, Prostran M.
    Journal: C R Seances Soc Biol Fil; 1985; 179(6):777-81. PubMed ID: 2939928.
    Abstract:
    Forskolin (0.375 mumol 1(-1)) produced positive inotropic and chronotropic effects on the isolated, spontaneously beating atria of the guinea pig. The same effects were also observed or even increased in the presence of various concentrations of isoprenaline (0.024 and 0.12 mumol 1(-1)) in the organ bath. The effects of forskolin on the isometric contraction and the atrial rate of the isolated, spontaneously beating atria of the guinea-pig were significantly inhibited by propranolol (9 mumol 1(-1)). These results indicate that the action of forskolin on the spontaneously beating atria of the guinea-pig is mediated by stimulation of the adenylate cyclase system, but in some steps of this action, a direct stimulation of beta-adrenoceptors might also be implicated.
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