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  • Title: beta-Endorphin-(1-27) inhibits the spinal beta-endorphin-induced release of Met-enkephalin.
    Author: Tseng LF, Li CH.
    Journal: Int J Pept Protein Res; 1986 Apr; 27(4):394-7. PubMed ID: 2940195.
    Abstract:
    The effect of intraventricular beta-endorphin-(1-27) on the spinal release of Met-enkephalin induced by intraventricular beta-endorphin was studied using the intrathecal superfusion technique in urethane anesthetized rats. Intraventricular injection of beta-endorphin at a dose of 15 micrograms released Met-enkephalin from the spinal cord. This release of Met-enkephalin induced by beta-endorphin was significantly reduced by beta-endorphin-(1-27), 60 micrograms, injected intraventricularly. Injection of beta-endorphin (1-27) itself did not cause any release of Met-enkephalin. The finding is in line with the previous report that beta-endorphin (1-27) inhibited the analgesia induced by beta-endorphin.
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