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  • Title: Antagonism of thromboxane actions in the isolated perfused rat heart.
    Author: Stahl GL, Darius H, Lefer AM.
    Journal: Life Sci; 1986 Jun 02; 38(22):2037-41. PubMed ID: 2940431.
    Abstract:
    The effects of SQ-29,548, a novel thromboxane A2 (TxA2) receptor antagonist, were studied in the isolated perfused rat heart. SQ-29,548 at concentrations of 2.5 to 50 ng/ml antagonized the increase in coronary perfusion pressure (CPP) in response to the thromboxane agonist, 9,11-methanoepoxy PGH2. Increases in CPP induced by arginine vasopressin and leukotriene D4 were not altered by SQ-29,548. We conclude that SQ-29,548 is a very potent and specific TxA2 receptor antagonist in the coronary vasculature of the rat heart.
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