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  • Title: Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease.
    Author: Yates CM, Simpson J, Gordon A.
    Journal: Neurosci Lett; 1986 Apr 11; 65(2):189-92. PubMed ID: 2940479.
    Abstract:
    5-Hydroxytryptamine (5-HT) and choline acetyltransferase (ChAT) were assayed in amygdala, cingulate cortex and caudate nucleus of post-mortem brains from 7 cases of Down's syndrome (6 with the neuropathological features of Alzheimer's disease and one with no such features), 9 cases of Alzheimer's disease and 12 controls. 5-HT was markedly reduced in all 3 areas of the pathologically affected Down brains, unaltered in the Down brain with no Alzheimer pathology and reduced in the amygdala and cingulate cortex of the Alzheimer brains. ChAT showed a similar pattern of reduction. These results supply biochemical evidence that 5-hydroxytryptaminergic, as well as cholinergic, neurons are reduced in Down's syndrome with Alzheimer pathology.
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