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  • Title: Synthesis of coumarin-theophylline hybrids as a new class of anti-tubercular and anti-microbial agents.
    Author: Mangasuli SN, Hosamani KM, Devarajegowda HC, Kurjogi MM, Joshi SD.
    Journal: Eur J Med Chem; 2018 Feb 25; 146():747-756. PubMed ID: 29407993.
    Abstract:
    A series of novel coumarin-theophylline hybrids were synthesized and examined for their anti-tubercular activity in vitro against Mycobacterium tuberculosis H37Rv, anti-microbial activity in vitro against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacterias (Escherichia coli, Salmonella typhi) as well as fungi (Candida albicans). The compound (3a) has shown excellent anti-tubercular activity with MIC of 0.12 μg/mL. Electron donating compounds (3a, 3f) have displayed significant anti-microbial activity. The compounds have also been precisely elucidated using single crystal X-ray diffraction techniques. Molecular docking study has been performed against 4DQU enzyme of Mycobacterium tuberculosis showed good binding interactions and is in agreement with the in vitro results.
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