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  • Title: [Venous thromboembolic disease and Klinefelter's syndrome].
    Author: Wautrecht JC, Vincent G, Dereume JP.
    Journal: J Mal Vasc; 1986; 11(2):125-7. PubMed ID: 2941508.
    Abstract:
    Venous thromboembolic disease was rarely described in association with Klinefelter's syndrome. It is nevertheless more frequent than in a genetically normal male population (5-20 times). This abnormality is not clearly explained. We report a classical case of Klinefelter's syndrome detected by the help of a venous thromboembolic disease. The patient was of blood-group A (the relative incidence of thrombosis is raised among group-A persons as compared with group-O persons). The evaluation disclosed a high rate of beta-thromboglobulin suggesting an underlying hypercoagulability. The abnormal incidence of venous thromboembolic disease among Klinefelter patients may find a partial explanation in this way.
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