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  • Title: Structure Determination and Characterization of a Family of Primary Alcohol Solvates.
    Author: Vasudevan KV, Peterson ML.
    Journal: J Pharm Sci; 2018 Jun; 107(6):1489-1497. PubMed ID: 29421220.
    Abstract:
    We report the preparation and structural characterization of a family of primary alcohol solvates of a small-molecule hydrochloride salt. The structures of the solvates are probed by powder and single crystal X-ray diffraction, and the compounds were additionally characterized by polarized light microscopy, thermogravimetric analysis, and dynamic scanning calorimetry. A comparison of the lattices of each compound is also provided. The results demonstrate the existence of a common solvating channel and highlight the importance of understanding the form landscape early in the development process.
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