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  • Title: Biocompatibility of a new polycarbonate dialysis membrane.
    Author: Knudsen F, Nielsen AH, Pedersen JO, Grunnet N, Jersild C.
    Journal: Blood Purif; 1986; 4(1-3):142-6. PubMed ID: 2942156.
    Abstract:
    The present report summarizes our experience with a new polycarbonate (PC)-based dialysis membrane (Gambro Lundia PRO-5) compared with a cuprophan (CP)-based membrane (Gambro Lundia 10-5N). Platelet count decreased during dialysis with CP, but was unchanged with PC membranes. Platelet injury, reflected by decreased platelet aggregation and increase in plasma beta-thromboglobulin, occurred equally with both membranes. Complement activation (C3d and C5a), leukopenia and release of granulocyte-derived elastase was more extensive with CP than with PC membranes. The new membrane represents an improvement of biocompatibility with respect to the complement-leukocyte system, whereas the effect on platelets resembles the injury caused by CP membranes.
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