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  • Title: Ionic liquid-enabled synthesis, cholinesterase inhibitory activity, and molecular docking study of highly functionalized tetrasubstituted pyrrolidines.
    Author: Kumar RS, Almansour AI, Arumugam N, Althomili DMQ, Altaf M, Basiri A, D K, Sai Manohar T, S V.
    Journal: Bioorg Chem; 2018 Apr; 77():263-268. PubMed ID: 29421701.
    Abstract:
    A small library of novel spiropyrrolidine heterocyclic hybrids has been prepared regioselectively in 1-butyl-3-methylimidazoliumbromide ([bmim]Br) with good to excellent yields using a [3+2] cycloaddition reaction. These synthesized compounds were evaluated as potential agents for treating Alzheimer's disease. Compound 4b showed the most potent activity, with an IC50 of 7.9 ± 0.25 µM against acetylcholinesterase (AChE). The inhibition mechanisms for the most active compounds on AChE and butyrylcholinesterase (BChE) receptors were elucidated using molecular docking simulations.
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