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  • Title: [Intracellular activity and secretion of various lysosomal glycosidases in cultured human skin fibroblasts].
    Author: Ivleva TS, Beliaeva ID, Vidershaĭn GIa.
    Journal: Biokhimiia; 1986 Jul; 51(7):1150-5. PubMed ID: 2942192.
    Abstract:
    The intracellular activities of four lysosomal glycosidases (alpha-L-fucosidase, beta-D-hexosaminidase, beta-D-galactosidase and beta-D-glucuronidase) in human skin fibroblasts cultured in a medium with 0.1% serum increased in a greater degree than that in a medium with 10% serum. Only two glycosidases (alpha-L-fucosidase and beta-D-hexosaminidase) were secreted by fibroblasts in the culture medium. The extracellular activity of alpha-L-fucosidase and beta-D-hexosaminidase was equivalent to 80 and 25% of their intracellular activity in serum-sufficient fibroblasts and 40 and 15%--in serum-restricted fibroblasts. These results suggest that the observer phenomena are controlled by the levels of autophagy, endocytosis and membrane recycling.
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