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  • Title: Ceftazidime in pediatric infections unsuccessfully treated with other antibiotics: an evaluation of its efficacy and tolerability in compromised host.
    Author: Boner AL, Castellani C, Fostini R, Padovani E.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1986 Jun; 24(6):333-6. PubMed ID: 2942496.
    Abstract:
    Ceftazidime (C) is a cephalosporine active against Gram-positive and especially negative bacteria. The aim of the study was to evaluate efficacy and tolerance of C in the treatment of children suffering from infections previously treated unsuccessfully with different antibiotics. We examined 20 children, administering a dosage of C 30 to 100 mg/kg intravenously or intramuscularly for a mean treatment duration of 8.6 days. A favorable response was observed in all the children: of the 20 patients 13 were cured and 7 improved. A transient elevation of liver enzymes was noted in three children. The study confirms the efficacy of C in the treatment of severe infections. Since 9 of the 20 patients were neonates, we suggest the possible role of C in the newborns' infections.
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