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  • Title: Control of arginine metabolism in Neurospora crassa. Role of feedback inhibition.
    Author: Goodman I, Weiss RL.
    Journal: J Biol Chem; 1986 Aug 05; 261(22):10264-70. PubMed ID: 2942539.
    Abstract:
    Flux through the arginine biosynthetic pathway of Neurospora crassa was measured under a variety of physiological conditions. Flux persisted, although at a reduced rate, in mutant strains resistant to feedback inhibition even after prolonged growth in the presence of exogenous arginine. Flux reverted to the uninhibited rate more quickly in feedback-resistant strains than in wild type strains upon removal of exogenous arginine. These results rule out enzyme repression as a major factor in controlling arginine biosynthesis. Feedback inhibition was shown to be independent of the size of the mycelial arginine pool or of the cytosolic arginine concentration, suggesting a role for the mitochondrial membrane in controlling the concentration of arginine at the site of inhibition--the mitochondrial matrix. The implications of these results are discussed.
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