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  • Title: Marrow relapse on maintenance chemotherapy in childhood acute lymphoblastic leukaemia.
    Author: Kearney PJ, Baumer JH, Howlett BC.
    Journal: Br J Cancer; 1979 Dec; 40(6):890-7. PubMed ID: 294291.
    Abstract:
    A retrospective study on 190 children with acute lymphoblastic leukaemia and marrow relapse on therapy demonstrated a universally poor prognosis with a high risk of extramedullary leukaemia. 49.1% of children achieved a second remission, the median duration of haematological remission being 97 days. The median duration of survival was 157 days, with no survivors beyond 2 years 3 months from relapse. Children with high white blood counts at diagnosis, those relapsing early and older children had a particularly poor prognosis. Children who achieved a first remission with difficulty and those receiving regular vincristine and prednisolone in their remission were less likely to achieve a second remission. Those who failed to go back into remission with the more commonly used drugs were not usually responsive to other drugs.
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