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  • Title: [Effect of tetracaine and sovcaine on the ATP-dependent calcium accumulation in sarcoplasmic reticulum vesicles of skeletal muscles].
    Author: Diadiusha GP, Zemlianaia NN.
    Journal: Ukr Biokhim Zh (1978); 1986; 58(4):40-5. PubMed ID: 2943066.
    Abstract:
    The tetracaine and cinchocaine in concentration less than 2 mM and 0.5 mM, respectively, stimulate ATP-dependent Ca-loading by enhancing the initial rate of Ca2+-accumulation, do not affect the Ca2+-binding and Ca-ATPase activity of sarcoplasmic reticulum vesicles. These data suggest blocking of Ca2+-efflux from vesicles which occurs during Ca-accumulation. Higher concentrations of the same compounds (above 2 mM and 0.5 mM for tetracaine and cinchocaine, respectively) caused inhibition of the Ca-ATPase activity and decreased the ability of SR vesicles to retain Ca2+, probably, due to their nonspecific lipophilic action.
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