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  • Title: Intracellular drug delivery: Potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy.
    Author: Luginbuehl V, Meier N, Kovar K, Rohrer J.
    Journal: Biotechnol Adv; 2018; 36(3):613-623. PubMed ID: 29432805.
    Abstract:
    A treasure trove of intracellular cancer drug targets remains hidden behind cell membranes. However, engineered pathogen-derived toxins such as Shiga toxins can deliver small or macromolecular drugs to specific intracellular organelles. After binding to ganglioglobotriaosylceramide (Gb3, CD77), the non-toxic subunit B (StxB) of the Shiga-holotoxin is endocytosed and delivers its payload by a unique retrograde trafficking pathway via the endoplasmic reticulum to the cytosol. This review provides an overview of biomedical applications of StxB-based drug delivery systems in targeted cancer diagnosis and therapy. Biotechnological production of the Stx-material is discussed from the perspective of developing efficacious and safe therapeutics.
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