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  • Title: Acid folic and pregnancy: A mandatory supplementation.
    Author: Valentin M, Coste Mazeau P, Zerah M, Ceccaldi PF, Benachi A, Luton D.
    Journal: Ann Endocrinol (Paris); 2018 Apr; 79(2):91-94. PubMed ID: 29433770.
    Abstract:
    Neural tube defects (NTD) occur in 0.5 to 2 per 1000 pregnancies with various handicaps for the affected child. It is now well established that folic acid deficiency (absolute or relative) is a predisposing factor to this type of malformation. Several randomized controlled trials showed that high-dose folic acid (4mg) is an essential factor for prevention of neural tube defects recurrence and significantly prevents the first occurrence of neural tube defects with a lower dose (0.4mg). Other etiologies can favor the occurrence of NTD such as MTHFR polymorphism, some antiepileptic therapies, obesity and pregestational mellitus diabetes. Necessity of a preconception folic acid supplementation or at least folate nutritional status evaluation should be known for all of us including patients and public.
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