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  • Title: Total Synthesis of Nucleoside Antibiotics Plicacetin and Streptcytosine A.
    Author: Fu J, Laval S, Yu B.
    Journal: J Org Chem; 2018 Jul 06; 83(13):7076-7084. PubMed ID: 29436226.
    Abstract:
    Disaccharide nucleoside antibiotics plicacetin and streptcytosine A (also named rocheicoside A) were effectively synthesized through the common precursor cytosamine. The amosamine and amicetose moieties were efficiently assembled through an α-selective O-glycosylation, and the cytosine nucleus was subsequently introduced through a β-selective gold(I)-catalyzed N-glycosylation. Further microwave-assisted amidation reactions completed the modular syntheses.
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