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  • Title: Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization.
    Author: Landegent JE, Jansen in de Wal N, Fisser-Groen YM, Bakker E, van der Ploeg M, Pearson PL.
    Journal: Hum Genet; 1986 Aug; 73(4):354-7. PubMed ID: 2943662.
    Abstract:
    The chromosomal localization of a unique DNA fragment, closely linked to Huntington disease (HD), was assessed in situ by hybridization with 2-acetylaminofluorene (AAF) modified probes. In these experiments, a cosmid cloned genomic fragment (c5.5) was used for hybridization. Here we present evidence that confirms the mapping of the D4S10 locus to the p16 region of chromosome 4 and assigns it to the telomere of the short arm.
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